Hypotheses and Research
Discover the groundbreaking research UC Well supports, including studies on hydrogen peroxide's role in UC and other innovative hypotheses.
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What is our foundation's
goals?
UC Well is dedicated to transforming the understanding and treatment of Ulcerative Colitis by challenging traditional assumptions and exploring innovative research avenues. The foundation emphasizes investigating potential root causes of UC, such as the role of hydrogen peroxide, aiming to move beyond symptom management and towards a definitive cure.
Help us find a cure to ulcerative colitis
By donating you help our foundation reach its goals to find a cure to ulcerative colitis
Our roadmap
1. Phase one
Objective: Initiate foundational studies to explore alternative hypotheses regarding UC's etiology.
Actions:
• Fund preliminary research projects focusing on proof of concept causes of UC.
• Collaborate with independent researchers and institutions to design studies examining the role of hydrogen peroxide in UC development.
• Develop and disseminate educational materials to raise awareness about alternative UC hypotheses.
Actions:
• Fund preliminary research projects focusing on proof of concept causes of UC.
• Collaborate with independent researchers and institutions to design studies examining the role of hydrogen peroxide in UC development.
• Develop and disseminate educational materials to raise awareness about alternative UC hypotheses.
2. Phase two
Objective: Broaden research initiatives and strengthen community support structures.
Actions:
• Support longitudinal studies to assess the efficacy of treatments targeting newly identified UC mechanisms.
• Organize workshops and seminars to share research findings with the medical community and the public.
• Establish support groups and peer networks for individuals affected by UC.
Actions:
• Support longitudinal studies to assess the efficacy of treatments targeting newly identified UC mechanisms.
• Organize workshops and seminars to share research findings with the medical community and the public.
• Establish support groups and peer networks for individuals affected by UC.
3. Phase three
Objective: Apply research findings to develop practical treatment approaches and influence clinical practices.
Actions:
• Collaborate with healthcare providers to pilot new treatment protocols based on research outcomes.
• Advocate for the inclusion of alternative UC treatment strategies in medical guidelines.
• Publish comprehensive reports detailing research findings and their implications for UC treatment.
Actions:
• Collaborate with healthcare providers to pilot new treatment protocols based on research outcomes.
• Advocate for the inclusion of alternative UC treatment strategies in medical guidelines.
• Publish comprehensive reports detailing research findings and their implications for UC treatment.
Research & Studies
New
Ulcerative colitis: Timeline to a cure
Pravda J.
World Journal of Gastroenterology
Jul 14, 2025
Pravda J.
World Journal of Gastroenterology
Jul 14, 2025
Read more
Pathlogists examine 180 colonic biopsies from patients with ulcerative colitis and conclude that the colitis is caused by a chemical secreted from the colonic epithelium.
SHIELDS WARREN, M.D., and SHELDON C. SOMMERS, M.D.
https://pmc.ncbi.nlm.nih.gov/
SHIELDS WARREN, M.D., and SHELDON C. SOMMERS, M.D.
https://pmc.ncbi.nlm.nih.gov/
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Report of ulcerative colitis in humans after hydrogen peroxide enemas.
C T Meyer, M Brand, V A DeLuca, H M Spir
March 3, 1981
C T Meyer, M Brand, V A DeLuca, H M Spir
March 3, 1981
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Seminal study showing mice unable to eliminate hydrogen peroxide develop colitis analogous to human ulcerative colitis.
R. STEVEN ESWORTHY,1 RICHARD ARANDA, MARTI´N G. MARTI´N, JAMES H. DOROSHOW,1 SCOTT W. BINDER, AND FONG-FONG CHU
Am J Physiol Gastrointest Liver Physiol
May 7, 2001
R. STEVEN ESWORTHY,1 RICHARD ARANDA, MARTI´N G. MARTI´N, JAMES H. DOROSHOW,1 SCOTT W. BINDER, AND FONG-FONG CHU
Am J Physiol Gastrointest Liver Physiol
May 7, 2001
Read more
Impairment of mitochondrial acetoacetyl CoA thiolase activity
in the colonic mucosa of patients with ulcerative colitis
Srikanth Santhanam, Aparna Venkatraman, Balakrishnan S Ramakrishna
https://pmc.ncbi.nlm.nih.gov/
April 18, 2007
in the colonic mucosa of patients with ulcerative colitis
Srikanth Santhanam, Aparna Venkatraman, Balakrishnan S Ramakrishna
https://pmc.ncbi.nlm.nih.gov/
April 18, 2007
Read more
Dr. Pravda indicating that hydrogen peroxide secreted by colonic epithelial cells is the cause of ulcerative colitis.
Pravda J.
World Journal of Gastroenterology
July 15, 2004
Pravda J.
World Journal of Gastroenterology
July 15, 2004
Read more
Sustained Histologic Remission (Complete Mucosal Healing) 12 Years after One-Time Treatment of Refractory Ulcerative Colitis with Novel Combination Therapy: A Case Report
Jay Pravda , Richard Gordon and Pamela B. Sylvestre
Journal of Inflammatory Bowel Diseases and Disorders
June 30, 2020
Jay Pravda , Richard Gordon and Pamela B. Sylvestre
Journal of Inflammatory Bowel Diseases and Disorders
June 30, 2020
Read more
Contact UC Well
Do you have a question about the foundation or would you like to learn more about our research program? Please send us a message, we will get back at you as soon as possible.
